RXFP1

Across TCGA cell cohorts, RXFP1 mutation is significantly associated with the mutation status of many other genes, with 3,004 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RXFP1-associated genes across cancer lineages are CNTNAP3, NOTCH4, and AGAP2. Each is linked with RXFP1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RXFP1-to-partner and partner-to-RXFP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CNTNAP3 grouped by RXFP1-low versus RXFP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RXFP1→partner) and Y-score (partner→RXFP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CNTNAP3 →	+3.050	+3.247	.008	.008	1	5
BREAST	NOTCH4 →	+4.857	+4.297	.009	.009	1	5
CNS	AGAP2 →	+4.459	+5.277	.005	.005	1	5
BLOOD_Leukemia	ARMC5 →	+3.243	+3.762	.001	.001	1	5
SKIN	SPTB →	+2.352	+4.062	.004	.004	1	4
LUNG_NSCLC_LUAD	PCDHB15 →	+4.772	+5.339	.004	.004	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,004 associations by consensus.

CNTNAP3 by RXFP1 expression — BLOOD_Leukemia

Explore this box plot interactively →