RWDD4

Across TCGA pan-cancer cohorts, RWDD4 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RWDD4 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher RWDD4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RWDD4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUAD show a favorable association.

PDAC, UCEC, and OV are the cancer types where RWDD4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.330	0.922	.001	22	view →
UCEC	DFS	Median	All	0.940	0.779	.007	10	view →
OV	DFS	Tertile	All	0.730	1.000	.036	8	view →
LUAD	OS	Quartile	II,III,IV	0.936	0.501	.006	8	view →
LSCC	OS	Median	All	0.793	1.000	.025	6	view →
HNSC	OS	Median	III,IV	1.000	0.484	.038	6	view →
GBM	DFS	Tertile	All	0.625	0.844	.014	5	view →
CCRCC	DFS	Median	III,IV	0.777	0.574	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RWDD4–PDAC (DFS)

Open the PDAC breakdown →