RWDD2B

Across TCGA pan-cancer cohorts, RWDD2B mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RWDD2B data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RWDD2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RWDD2B expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

LUAD, PDAC, and CCRCC are the cancer types where RWDD2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.706	0.982	.003	39	view →
PDAC	OS	Quartile	II,III,IV	0.633	0.947	.017	6	view →
CCRCC	DFS	Tertile	All	0.840	0.540	.025	5	view →
GBM	OS	Quartile	All	0.214	0.516	.021	4	view →
HNSC	OS	Quartile	II,III,IV	1.000	0.920	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RWDD2B–LUAD (DFS)

Open the LUAD breakdown →