RWDD2B

Across TCGA patient cohorts, RWDD2B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RWDD2B-associated genes across cancer lineages are N-Cadherin, p27_pT198, and p90 RSK. Each is linked with RWDD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both RWDD2B-to-partner and partner-to-RWDD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, N-Cadherin grouped by RWDD2B-low versus RWDD2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RWDD2B→partner) and Y-score (partner→RWDD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	N-Cadherin →	-0.359	-3.169	.002	.020	3	1
UCEC	p27_pT198 →	+0.127	+3.169	.031	.020	3	1
UCEC	p90 RSK →	+0.266	+3.183	.011	.010	3	1
UCEC	Tuberin_pT1462 →	+0.332	+3.169	.008	.020	3	1
UCEC	Tuberin →	+0.380	+2.817	.010	.036	3	1
UCEC	Bid →	-0.162	-3.169	.013	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

N-Cadherin by RWDD2B expression — UCEC

Explore this box plot interactively →