RUSC2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RUSC2 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUSC2-associated genes across cancer lineages are VHL, 14-3-3_beta, and ERK2. Each is linked with RUSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUSC2-to-partner and partner-to-RUSC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSC2→partner) and Y-score (partner→RUSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
STADVHL →+0.867+3.000.033.03632
UCEC14-3-3_beta →-0.077-1.558.009.03232
UCECERK2 →+0.216+2.099<.001<.00132
UCECINPP4B →-0.188-1.847.048.00732
UCECMEK1 →+0.384+1.637<.001.00132
UCECMSH2 →-0.293-3.366<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Exploration