Across TCGA cell cohorts, RUSC2 mutation is significantly associated with the RNA expression of many other genes, with 264 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUSC2-associated genes across cancer lineages are SRMS, SPATA16, and ZSCAN5C. Each is linked with RUSC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUSC2-to-partner and partner-to-RUSC2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUSC2→partner) and Y-score (partner→RUSC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	SRMS →	+0.043	+3.754	<.001	.002	3	2
SOFT_TISSUE	SPATA16 →	+0.037	+2.874	.003	.008	3	2
SOFT_TISSUE	ZSCAN5C →	+0.018	+3.872	<.001	.002	3	2
LARGE_INTESTINE	ZUP1 →	+0.621	+2.628	.001	.002	3	2
LARGE_INTESTINE	PGAM5 →	+0.520	+3.064	.002	.009	3	2
SOFT_TISSUE	DNAH8 →	+0.313	+3.679	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 264 associations by consensus.

Exploration

RUSC2 survival (RNA) · tumor vs normal (RNA) · all RUSC2 data types