Across TCGA pan-cancer cohorts, RUSC1-AS1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RUSC1-AS1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RUSC1-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RUSC1-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and BRCA show a favorable association.

ACC, KIRC, and CESC are the cancer types where RUSC1-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.273	0.630	<.001	106	view →
KIRC	DFS	Median	All	0.468	0.701	<.001	94	view →
CESC	DFS	Median	All	0.419	0.690	<.001	44	view →
LIHC	DFS	Quartile	All	0.393	0.588	<.001	41	view →
UVM	DFS	Quartile	All	0.326	0.786	.004	40	view →
BLCA	OS	Tertile	II,III,IV	0.570	0.413	.013	35	view →
COAD	DFS	Quartile	All	0.394	0.758	.004	32	view →
BRCA	OS	Median	III,IV	0.610	0.478	.012	23	view →
SKCM	DFS	Quartile	II,III,IV	0.164	0.507	.002	20	view →
PRAD	DFS	Median	All	0.712	0.832	<.001	20	view →
MESO	DFS	Median	IV	0.145	0.478	<.001	15	view →
CHOL	OS	Quartile	All	0.450	0.903	.020	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

Exploration

Same gene, other analysis: RUSC1-AS1 tumor-vs-normal RNA expression · all RUSC1-AS1 data types