RUNX3

Across TCGA patient cohorts, RUNX3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX3-associated genes across cancer lineages are Annexin-1, ATM, and Di-Ras3. Each is linked with RUNX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNX3-to-partner and partner-to-RUNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RUNX3-low versus RUNX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX3→partner) and Y-score (partner→RUNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.557	+2.341	.008	.019	3	2
UCEC	ATM →	-0.409	-2.308	.025	.033	3	2
UCEC	Di-Ras3 →	-0.199	-2.415	<.001	.003	3	2
UCEC	A-Raf_pS299 →	-0.118	-2.459	.014	.019	3	1
UCEC	FOXO3a →	-0.109	-1.970	.007	.030	3	1
UCEC	IGFBP2 →	-0.743	-2.459	.004	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Annexin-1 by RUNX3 expression — UCEC

Explore this box plot interactively →