RUNX3

Across TCGA cell cohorts, RUNX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,349 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RUNX3-associated GO terms across cancer lineages are Translational initiation, Nuclear transport, and Nucleocytoplasmic transport. Each is linked with RUNX3 in more than 9 cancer types. Because this analysis shows association rather than direction, both RUNX3-to-partner and partner-to-RUNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Translational initiation grouped by RUNX3-low versus RUNX3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX3→partner) and Y-score (partner→RUNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Translational initiation →	+0.107	+2.120	<.001	<.001	3	10
OESOPHAGUS	Nuclear transport →	+0.073	+1.721	<.001	<.001	3	10
OESOPHAGUS	Nucleocytoplasmic transport →	+0.073	+1.721	<.001	<.001	3	9
OESOPHAGUS	Protein import into nucleus →	+0.071	+2.009	.003	.001	3	9
BREAST	Regulation of telomerase RNA localization to Cajal body →	+0.099	+1.953	<.001	<.001	3	9
OESOPHAGUS	DNA-templated transcription initiation →	+0.081	+2.202	.003	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,349 associations by consensus.

Translational initiation by RUNX3 expression — OESOPHAGUS

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