RUNX3

Across TCGA cell cohorts, RUNX3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RUNX3-associated genes across cancer lineages are FASLG, SLC3A1, and OXGR1. Each is linked with RUNX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNX3-to-partner and partner-to-RUNX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASLG grouped by RUNX3-low versus RUNX3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX3→partner) and Y-score (partner→RUNX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FASLG →	+0.090	+2.762	.002	.006	3	1
BLOOD_Leukemia	SLC3A1 →	+0.078	+3.389	.009	.007	3	1
BLOOD_Leukemia	OXGR1 →	+0.083	+2.847	<.001	.002	3	1
BLOOD_Leukemia	FBXL7 →	+0.589	+3.634	.002	.002	3	1
BLOOD_Leukemia	PRSS55 →	+0.045	+2.897	<.001	.004	3	1
BLOOD_Leukemia	CGB8 →	+0.041	+2.644	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

FASLG by RUNX3 expression — BLOOD_Leukemia

Explore this box plot interactively →