RUNX2-AS1

Across TCGA pan-cancer cohorts, RUNX2-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated RUNX2-AS1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher RUNX2-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RUNX2-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and STAD show a favorable association.

KICH, PAAD, and LIHC are the cancer types where RUNX2-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	III,IV	0.178	0.847	<.001	108	view →
PAAD	DFS	Tertile	II,III,IV	0.636	0.244	.007	39	view →
LIHC	OS	Tertile	III,IV	0.282	0.551	.008	36	view →
SARC	DFS	Tertile	All	0.330	0.572	<.001	29	view →
KIRC	DFS	Tertile	All	0.734	0.824	<.001	28	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
BLCA	OS	Tertile	IV	0.217	0.626	.001	18	view →
COAD	DFS	Tertile	II,III,IV	0.594	0.758	.028	15	view →
GBM	DFS	Tertile	All	0.081	0.305	<.001	9	view →
STAD	OS	Quartile	All	0.774	0.608	.014	5	view →
THCA	DFS	Tertile	IV	0.865	0.574	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

RUNX2-AS1–KICH (OS)

Open the KICH breakdown →