RUNX1T1

Across TCGA patient cohorts, RUNX1T1 mutation is significantly associated with the RNA expression of many other genes, with 4,053 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX1T1-associated genes across cancer lineages are KIF23, TIPIN, and ATF4P2. Each is linked with RUNX1T1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RUNX1T1-to-partner and partner-to-RUNX1T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF23 grouped by RUNX1T1-low versus RUNX1T1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1T1→partner) and Y-score (partner→RUNX1T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KIF23 →	+0.385	+1.238	.004	.005	3	5
UCEC	TIPIN →	+0.291	+1.609	.001	<.001	3	5
LGG	ATF4P2 →	+0.050	+4.506	<.001	.005	3	4
LUAD	CDKN3 →	+0.863	+3.486	.003	.002	2	5
HNSC	PSMD9 →	+0.302	+2.795	<.001	.002	3	4
UCEC	SERAC1 →	+0.292	+1.173	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,053 associations by consensus.

KIF23 by RUNX1T1 expression — UCEC

Explore this box plot interactively →