RUNX1T1

Across TCGA patient cohorts, RUNX1T1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX1T1-associated genes across cancer lineages are Annexin-1, Src_pY416, and ASNS. Each is linked with RUNX1T1 in more than 4 cancer types. Because this analysis shows association rather than direction, both RUNX1T1-to-partner and partner-to-RUNX1T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by RUNX1T1-low versus RUNX1T1-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1T1→partner) and Y-score (partner→RUNX1T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	Annexin-1 →	+0.531	+3.000	.019	.033	1	5
LUAD	Src_pY416 →	-0.306	-1.983	.026	.031	3	3
LUAD	ASNS →	+0.470	+3.169	.018	.018	3	3
UCEC	GAPDH →	+0.272	+1.247	.047	.038	3	3
UCEC	PDCD4 →	-0.288	-1.362	.016	.031	3	3
LUSC	FoxM1 →	+0.248	+3.340	.011	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Annexin-1 by RUNX1T1 expression — CESC

Explore this box plot interactively →