RUNX1T1

Across TCGA cell cohorts, RUNX1T1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,108 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible RUNX1T1-associated GO terms across cancer lineages are Regulation of endoplasmic reticulum tubular network organization, Positive regulation of endoplasmic reticulum tubular network organization, and Spliceosomal complex assembly. Each is linked with RUNX1T1 in more than 5 cancer types. Because this analysis shows association rather than direction, both RUNX1T1-to-partner and partner-to-RUNX1T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of endoplasmic reticulum tubular network organization grouped by RUNX1T1-low versus RUNX1T1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1T1→partner) and Y-score (partner→RUNX1T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of endoplasmic reticulum tubular network organization →	+0.134	+2.432	<.001	<.001	3	6
LUNG_SCLC	Positive regulation of endoplasmic reticulum tubular network organization →	+0.132	+2.432	<.001	<.001	3	6
SKIN	Spliceosomal complex assembly →	+0.073	+0.582	.001	.005	3	5
SKIN	Nuclear transport →	+0.051	+0.691	<.001	<.001	2	6
SKIN	Regulation of dopamine receptor signaling pathway →	-0.145	-0.424	<.001	.004	3	5
SOFT_TISSUE	Endoplasmic reticulum to Golgi vesicle-mediated transport →	+0.068	+1.175	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,108 associations by consensus.

Regulation of endoplasmic reticulum tubular network organization by RUNX1T1 expression — LUNG_SCLC

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