RUNX1T1

Across TCGA cell cohorts, RUNX1T1 mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUNX1T1-associated genes across cancer lineages are TBL1Y, OR52B2, and LANCL1. Each is linked with RUNX1T1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUNX1T1-to-partner and partner-to-RUNX1T1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBL1Y grouped by RUNX1T1-low versus RUNX1T1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1T1→partner) and Y-score (partner→RUNX1T1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TBL1Y →	+0.005	+4.614	<.001	.004	3	3
PANCREAS	OR52B2 →	+0.027	+4.786	.001	.001	3	2
LARGE_INTESTINE	LANCL1 →	+0.750	+2.502	.004	.005	3	2
LUNG_NSCLC_LUAD	LUZP4 →	+0.035	+3.536	<.001	.001	3	2
PANCREAS	FABP12 →	+0.104	+4.237	<.001	.006	3	1
BLOOD_Lymphoma	PTPRT →	+1.197	+3.819	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

TBL1Y by RUNX1T1 expression — PANCREAS

Explore this box plot interactively →