RUNX1

Across TCGA patient cohorts, RUNX1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNX1-associated genes across cancer lineages are ATM, c-Met_pY1235, and eIF4E. Each is linked with RUNX1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUNX1-to-partner and partner-to-RUNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RUNX1-low versus RUNX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1→partner) and Y-score (partner→RUNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.524	-2.321	<.001	<.001	3	3
UCEC	c-Met_pY1235 →	+0.047	+1.378	.034	.008	3	3
UCEC	eIF4E →	+0.144	+2.013	.022	.016	3	2
UCEC	INPP4B →	-0.242	-1.765	.011	.011	3	2
UCEC	PCNA →	+0.180	+1.584	.005	.002	3	2
UCEC	Rab25 →	-0.331	-3.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

ATM by RUNX1 expression — UCEC

Explore this box plot interactively →