RUNX1

Across TCGA cell cohorts, RUNX1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,194 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RUNX1-associated GO terms across cancer lineages are Cardiac muscle tissue regeneration, Positive regulation of CD8-positive, alpha-beta T cell differentiation, and Regulation of protein localization to mitochondrion. Each is linked with RUNX1 in more than 16 cancer types. Because this analysis shows association rather than direction, both RUNX1-to-partner and partner-to-RUNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cardiac muscle tissue regeneration grouped by RUNX1-low versus RUNX1-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1→partner) and Y-score (partner→RUNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Cardiac muscle tissue regeneration →	+1.107	+2.017	<.001	<.001	3	17
LUNG_NSCLC_LUSC	Positive regulation of CD8-positive, alpha-beta T cell differentiation →	+0.310	+1.649	<.001	.002	3	14
LIVER	Regulation of protein localization to mitochondrion →	+0.116	+1.677	<.001	<.001	3	14
BONE	Regulation of transforming growth factor beta receptor signaling pathway →	+0.061	+2.596	<.001	<.001	3	14
BONE	Regulation of cellular response to transforming growth factor beta stimulus →	+0.064	+2.596	<.001	<.001	3	14
LIVER	Positive regulation of extracellular matrix organization →	+0.194	+2.561	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,194 associations by consensus.

Cardiac muscle tissue regeneration by RUNX1 expression — BLOOD_Myeloma

Explore this box plot interactively →