RUNX1

Across TCGA cell cohorts, RUNX1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RUNX1-associated genes across cancer lineages are ASB17, MYMK, and MTRNR2L10. Each is linked with RUNX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNX1-to-partner and partner-to-RUNX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by RUNX1-low versus RUNX1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNX1→partner) and Y-score (partner→RUNX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.014	+4.222	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	MYMK →	+0.030	+4.510	<.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	MTRNR2L10 →	+0.096	+4.209	.004	.006	3	1
LUNG_NSCLC_LUAD	OR2T29 →	+0.008	+4.681	<.001	.003	3	1
LUNG_NSCLC_LUAD	SERPINA11 →	+0.833	+3.947	<.001	.004	3	1
LUNG_NSCLC_LUAD	NCR2 →	+0.013	+4.078	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

ASB17 by RUNX1 expression — OVARY

Explore this box plot interactively →