RUNDC3A

Across TCGA patient cohorts, RUNDC3A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUNDC3A-associated genes across cancer lineages are eIF4E, A-Raf_pS299, and JNK2. Each is linked with RUNDC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNDC3A-to-partner and partner-to-RUNDC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by RUNDC3A-low versus RUNDC3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNDC3A→partner) and Y-score (partner→RUNDC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.193	+2.906	.031	.001	3	1
UCEC	A-Raf_pS299 →	-0.104	-2.459	.040	.019	3	1
UCEC	JNK2 →	+0.235	+2.834	.005	.034	3	1
UCEC	MEK1 →	+0.427	+2.906	.005	.001	3	1
UCEC	p21 →	+0.188	+3.000	.021	.036	3	1
UCEC	p90 RSK →	+0.172	+2.594	.034	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by RUNDC3A expression — UCEC

Explore this box plot interactively →