RUNDC3A

Across TCGA cell cohorts, RUNDC3A mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RUNDC3A-associated genes across cancer lineages are OR11H4, PNMA3, and C16orf96. Each is linked with RUNDC3A in more than 1 cancer types. Because this analysis shows association rather than direction, both RUNDC3A-to-partner and partner-to-RUNDC3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR11H4 grouped by RUNDC3A-low versus RUNDC3A-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUNDC3A→partner) and Y-score (partner→RUNDC3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR11H4 →	+0.106	+2.878	.002	.009	3	1
LARGE_INTESTINE	PNMA3 →	+0.217	+2.781	<.001	.009	3	1
LARGE_INTESTINE	C16orf96 →	+0.519	+3.520	.003	.005	3	1
LARGE_INTESTINE	RNF212B →	+0.112	+3.000	<.001	.006	3	1
LARGE_INTESTINE	CENPVL1 →	+0.141	+2.925	<.001	.007	3	1
LARGE_INTESTINE	OR4A47 →	+0.012	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR11H4 by RUNDC3A expression — LARGE_INTESTINE

Explore this box plot interactively →