Across TCGA patient cohorts, RUFY4 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUFY4-associated genes across cancer lineages are FoxM1, STAT3_pY705, and ASNS. Each is linked with RUFY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUFY4-to-partner and partner-to-RUFY4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY4→partner) and Y-score (partner→RUFY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.245	+3.169	.028	.019	3	2
UCEC	STAT3_pY705 →	-0.276	-2.212	.005	.010	3	2
UCEC	ASNS →	+0.273	+1.874	.044	.049	3	2
UCEC	ATM →	-0.424	-3.459	.012	.005	3	2
UCEC	4E-BP1 →	+0.282	+3.169	.005	.018	3	2
SKCM	PRAS40_pT246 →	+0.187	+2.820	.029	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

RUFY4 survival (RNA) · tumor vs normal (RNA) · all RUFY4 data types