Across TCGA cell cohorts, RUFY4 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RUFY4-associated genes across cancer lineages are TTLL8, TBC1D21, and LCN1. Each is linked with RUFY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUFY4-to-partner and partner-to-RUFY4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY4→partner) and Y-score (partner→RUFY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.015	+5.022	<.001	.002	3	1
BLOOD_Leukemia	LCN1 →	+0.057	+4.922	<.001	.009	3	1
LUNG_NSCLC_LUAD	UNC93A →	+0.442	+3.544	<.001	.008	3	1
LUNG_NSCLC_LUAD	HES3 →	+0.064	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR56A1 →	+0.265	+3.604	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

RUFY4 survival (RNA) · tumor vs normal (RNA) · all RUFY4 data types