RUFY3

Across TCGA patient cohorts, RUFY3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUFY3-associated genes across cancer lineages are ATM, 4E-BP1, and C-Raf. Each is linked with RUFY3 in more than 2 cancer types. Because this analysis shows association rather than direction, both RUFY3-to-partner and partner-to-RUFY3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RUFY3-low versus RUFY3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY3→partner) and Y-score (partner→RUFY3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.503	-3.446	<.001	.005	3	3
UCEC	4E-BP1 →	+0.341	+3.807	<.001	<.001	3	2
UCEC	C-Raf →	+0.117	+1.321	.015	.029	3	2
UCEC	eIF4E →	+0.183	+3.598	.009	.001	3	1
UCEC	eIF4G →	+0.256	+1.321	.013	.029	3	1
UCEC	ERK2 →	+0.148	+1.321	.022	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by RUFY3 expression — UCEC

Explore this box plot interactively →