RUFY2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RUFY2 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUFY2-associated genes across cancer lineages are p53, ATM, and Caspase-7-cleavedD198. Each is linked with RUFY2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUFY2-to-partner and partner-to-RUFY2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY2→partner) and Y-score (partner→RUFY2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECp53 →-0.308-3.321.015.00932
UCECATM →-0.465-1.765.001.01332
UCECCaspase-7-cleavedD198 →+0.544+1.785.005.00732
UCECC-Raf →+0.163+1.847<.001.00732
UCECCyclin-B1 →+0.780+2.263<.001<.00132
UCEC14-3-3_beta →-0.144-2.249<.001<.00131
Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

Exploration