RUFY1

Across TCGA patient cohorts, RUFY1 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RUFY1-associated genes across cancer lineages are A-Raf_pS299, PRAS40_pT246, and STAT3_pY705. Each is linked with RUFY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUFY1-to-partner and partner-to-RUFY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by RUFY1-low versus RUFY1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY1→partner) and Y-score (partner→RUFY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.138	-2.000	.003	.030	3	2
UCEC	PRAS40_pT246 →	+0.171	+1.598	.011	.022	3	2
UCEC	STAT3_pY705 →	-0.376	-1.797	<.001	.025	3	2
UCEC	eIF4E →	+0.165	+2.000	.046	.010	3	1
UCEC	eIF4G →	+0.354	+2.000	.003	.010	3	1
UCEC	ERK2 →	+0.167	+2.000	.027	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

A-Raf_pS299 by RUFY1 expression — UCEC

Explore this box plot interactively →