RUFY1

Across TCGA cell cohorts, RUFY1 mutation is significantly associated with the RNA expression of many other genes, with 53 significant associations in total. UPPER_AERODIGESTIVE_TRACT shows the largest number of these associations.

The most reproducible RUFY1-associated genes across cancer lineages are C1orf141, EDDM3B, and PRAMEF7. Each is linked with RUFY1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RUFY1-to-partner and partner-to-RUFY1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf141 grouped by RUFY1-low versus RUFY1-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RUFY1→partner) and Y-score (partner→RUFY1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	C1orf141 →	+0.133	+5.000	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	EDDM3B →	+0.043	+5.357	<.001	.003	3	2
UPPER_AERODIGESTIVE_TRACT	PRAMEF7 →	+0.116	+4.736	<.001	.009	3	2
LUNG_NSCLC_LUAD	DPRX →	+0.273	+5.228	<.001	.005	3	2
UPPER_AERODIGESTIVE_TRACT	GML →	+0.147	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	PRAMEF2 →	+0.182	+4.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

C1orf141 by RUFY1 expression — KIDNEY

Explore this box plot interactively →