RUBCN

Across TCGA pan-cancer cohorts, RUBCN mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RUBCN data layer compared with 17 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RUBCN mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RUBCN expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

LUAD, LSCC, and UCEC are the cancer types where RUBCN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.143	0.749	<.001	14	view →
LSCC	DFS	Median	II,III,IV	0.862	0.965	.017	13	view →
UCEC	OS	Median	III,IV	1.000	0.560	.042	4	view →
CCRCC	DFS	Tertile	II,III,IV	0.845	0.566	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RUBCN–LUAD (DFS)

Open the LUAD breakdown →