RTTN

Across TCGA pan-cancer cohorts, RTTN mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RTTN data layer compared with 25 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher RTTN mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RTTN expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and UCEC are the cancer types where RTTN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	1.000	0.553	.009	6	view →
HNSC	DFS	Median	II,III,IV	0.985	0.889	.017	5	view →
UCEC	DFS	Quartile	All	1.000	0.823	.025	4	view →
LUAD	DFS	Tertile	All	1.000	0.623	.022	3	view →
PDAC	DFS	Tertile	II,III,IV	0.290	0.678	.035	2	view →
GBM	OS	Median	All	0.923	0.690	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RTTN–LSCC (DFS)

Open the LSCC breakdown →