RTTN

Across TCGA patient cohorts, RTTN mutation is significantly associated with the RNA expression of many other genes, with 3,804 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTTN-associated genes across cancer lineages are KIF2C, CHAF1B, and RAD51. Each is linked with RTTN in more than 5 cancer types. Because this analysis shows association rather than direction, both RTTN-to-partner and partner-to-RTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIF2C grouped by RTTN-low versus RTTN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTTN→partner) and Y-score (partner→RTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KIF2C →	+0.887	+2.535	<.001	<.001	3	6
COAD	CHAF1B →	+0.707	+3.611	<.001	.001	3	5
COAD	RAD51 →	+0.680	+3.331	<.001	.005	3	5
STAD	ORC1 →	+0.768	+3.207	.007	.009	3	5
LUAD	GTSE1 →	+0.599	+4.017	.004	<.001	3	5
UCEC	TRMU →	+0.388	+1.747	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,804 associations by consensus.

KIF2C by RTTN expression — LUAD

Explore this box plot interactively →