RTTN

Across TCGA patient cohorts, RTTN mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTTN-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and Cyclin-B1. Each is linked with RTTN in more than 4 cancer types. Because this analysis shows association rather than direction, both RTTN-to-partner and partner-to-RTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RTTN-low versus RTTN-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTTN→partner) and Y-score (partner→RTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ASNS →	+0.516	+2.321	.004	.006	3	5
UCEC	Caspase-7-cleavedD198 →	+0.655	+2.479	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.553	+1.485	<.001	.003	3	3
LUSC	Src_pY416 →	-0.265	-1.575	.045	.035	3	2
STAD	c-Kit →	-0.313	-3.169	.045	.019	3	2
COAD	MIG-6 →	+0.126	+3.229	.009	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

ASNS by RTTN expression — LUAD

Explore this box plot interactively →