RTTN

Across TCGA cell cohorts, RTTN mutation is significantly associated with the RNA expression of many other genes, with 1,027 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTTN-associated genes across cancer lineages are RPL10L, TAS2R38, and MTO1. Each is linked with RTTN in more than 2 cancer types. Because this analysis shows association rather than direction, both RTTN-to-partner and partner-to-RTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL10L grouped by RTTN-low versus RTTN-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTTN→partner) and Y-score (partner→RTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPL10L →	+0.038	+4.930	<.001	.008	3	2
SOFT_TISSUE	TAS2R38 →	+0.035	+5.369	<.001	.004	3	2
LARGE_INTESTINE	MTO1 →	+0.671	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	PLTP →	-1.833	-3.459	.001	<.001	3	2
LARGE_INTESTINE	MAPK8 →	+0.628	+2.537	.001	<.001	3	2
LARGE_INTESTINE	C1QBP →	+0.670	+2.590	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,027 associations by consensus.

RPL10L by RTTN expression — SOFT_TISSUE

Explore this box plot interactively →