RTTN

Across TCGA cell cohorts, RTTN mutation is significantly associated with the mutation status of many other genes, with 4,423 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTTN-associated genes across cancer lineages are FLNB, RYR3, and ZFHX4. Each is linked with RTTN in more than 5 cancer types. Because this analysis shows association rather than direction, both RTTN-to-partner and partner-to-RTTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLNB grouped by RTTN-low versus RTTN-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTTN→partner) and Y-score (partner→RTTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FLNB →	+2.156	+2.364	<.001	<.001	1	6
BLOOD_Myeloma	RYR3 →	+3.285	+3.906	.009	.009	1	5
KIDNEY	ZFHX4 →	+2.817	+4.011	.009	.009	1	5
BONE	DNAH9 →	+3.655	+3.954	.003	.003	1	5
STOMACH	ROBO1 →	+3.942	+4.584	.002	.002	1	5
LARGE_INTESTINE	MECOM →	+2.030	+1.874	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,423 associations by consensus.

FLNB by RTTN expression — BLOOD_Leukemia

Explore this box plot interactively →