RTRAF

Across TCGA pan-cancer cohorts, RTRAF mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RTRAF data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher RTRAF mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RTRAF expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

COAD, UCEC, and PDAC are the cancer types where RTRAF mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.886	.020	24	view →
UCEC	OS	Median	III,IV	0.433	1.000	.007	24	view →
PDAC	DFS	Quartile	All	0.838	0.662	.009	18	view →
CCRCC	DFS	Median	III,IV	0.928	0.128	.014	9	view →
HNSC	OS	Median	IV	0.603	0.846	.007	8	view →
LSCC	OS	Median	III,IV	0.457	0.846	.023	5	view →
GBM	DFS	Quartile	All	0.481	0.245	.027	3	view →
LUAD	DFS	Median	III,IV	0.432	0.925	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RTRAF–COAD (DFS)

Open the COAD breakdown →