RTP1

Across TCGA patient cohorts, RTP1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTP1-associated genes across cancer lineages are ATM, MIG-6, and eEF2. Each is linked with RTP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTP1-to-partner and partner-to-RTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RTP1-low versus RTP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTP1→partner) and Y-score (partner→RTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.607	-2.986	.002	.035	3	2
COAD	MIG-6 →	+0.143	+2.866	.008	.033	3	2
UCEC	eEF2 →	+0.396	+3.000	.011	.036	2	2
UCEC	ERK2 →	+0.279	+3.169	<.001	.018	3	1
UCEC	FOXO3a_pS318_S321 →	-0.138	-3.449	.011	.005	3	1
UCEC	INPP4B →	-0.364	-3.169	.009	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ATM by RTP1 expression — UCEC

Explore this box plot interactively →