RTP1

Across TCGA cell cohorts, RTP1 mutation is significantly associated with the RNA expression of many other genes, with 130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RTP1-associated genes across cancer lineages are TXNDC15, ZNF644, and PRDM7. Each is linked with RTP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTP1-to-partner and partner-to-RTP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TXNDC15 grouped by RTP1-low versus RTP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTP1→partner) and Y-score (partner→RTP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TXNDC15 →	+0.658	+3.212	.001	.006	3	1
LARGE_INTESTINE	ZNF644 →	+0.440	+3.212	.005	.006	3	1
LARGE_INTESTINE	PRDM7 →	+0.181	+3.494	<.001	.002	3	1
LARGE_INTESTINE	MGAT3 →	-1.298	-3.169	.003	.009	3	1
LARGE_INTESTINE	GALR3 →	+0.075	+3.602	.007	.005	3	1
LARGE_INTESTINE	BTF3L4 →	+0.699	+3.212	.003	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 130 associations by consensus.

TXNDC15 by RTP1 expression — LARGE_INTESTINE

Explore this box plot interactively →