Across TCGA pan-cancer cohorts, RTN4RL1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RTN4RL1 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher RTN4RL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTN4RL1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

DLBC, PRAD, and SARC are the cancer types where RTN4RL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
PRAD	OS	Median	All	0.125	0.883	<.001	12	view →
SARC	OS	Median	All	0.156	0.767	.001	6	view →
ESCA	DFS	Median	II,III,IV	0.149	0.522	.047	3	view →
UCEC	DFS	Median	All	1.000	0.632	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: RTN4RL1 tumor-vs-normal RNA expression · all RTN4RL1 data types