RTN4R

Across TCGA pan-cancer cohorts, RTN4R mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated RTN4R data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher RTN4R mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RTN4R expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM and LSCC are the cancer types where RTN4R mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Quartile	All	0.864	0.601	<.001	14	view →
LSCC	DFS	Median	II,III,IV	1.000	0.429	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

RTN4R–GBM (DFS)

Open the GBM breakdown →