RTN4IP1

Across TCGA patient cohorts, RTN4IP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN4IP1-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and Ku80. Each is linked with RTN4IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN4IP1-to-partner and partner-to-RTN4IP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by RTN4IP1-low versus RTN4IP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN4IP1→partner) and Y-score (partner→RTN4IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.289	-1.906	.004	.016	3	2
UCEC	A-Raf_pS299 →	-0.190	-3.087	<.001	<.001	3	1
UCEC	Ku80 →	+0.258	+1.498	.006	.036	3	1
UCEC	MEK1 →	+0.469	+3.087	.001	<.001	3	1
UCEC	Myosin-IIa_pS1943 →	+0.208	+1.498	.012	.036	3	1
UCEC	Myosin-IIa →	+0.159	+1.492	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by RTN4IP1 expression — UCEC

Explore this box plot interactively →