RTN4

Across TCGA pan-cancer cohorts, RTN4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated RTN4 data layer compared with 28 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher RTN4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTN4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, LUSC, and ESCA are the cancer types where RTN4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	III,IV	0.068	0.756	<.001	22	view →
LUSC	OS	Median	III,IV	0.500	0.664	<.001	20	view →
ESCA	OS	Median	II,III,IV	0.232	0.706	<.001	15	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.955	0.827	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

RTN4–CESC (OS)

Open the CESC breakdown →