RTN4

Across TCGA patient cohorts, RTN4 mutation is significantly associated with the RNA expression of many other genes, with 4,531 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN4-associated genes across cancer lineages are NCAPD3, OTUD3, and ZNF850. Each is linked with RTN4 in more than 2 cancer types. Because this analysis shows association rather than direction, both RTN4-to-partner and partner-to-RTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCAPD3 grouped by RTN4-low versus RTN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN4→partner) and Y-score (partner→RTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPD3 →	+0.767	+2.010	<.001	<.001	3	3
UCEC	OTUD3 →	+0.445	+1.541	<.001	.002	3	3
UCEC	ZNF850 →	+0.537	+2.673	<.001	<.001	3	3
UCEC	DMAC2 →	+0.268	+3.087	.009	<.001	3	3
UCEC	GOT1 →	+0.437	+2.064	<.001	<.001	3	3
UCEC	PIN1 →	+0.333	+2.687	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,531 associations by consensus.

NCAPD3 by RTN4 expression — UCEC

Explore this box plot interactively →