RTN4

Across TCGA patient cohorts, RTN4 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN4-associated genes across cancer lineages are 14-3-3_beta, FoxM1, and MEK1. Each is linked with RTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN4-to-partner and partner-to-RTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RTN4-low versus RTN4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN4→partner) and Y-score (partner→RTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	14-3-3_beta →	-0.232	-2.974	.028	.036	3	2
UCEC	FoxM1 →	+0.234	+2.321	.005	<.001	3	2
UCEC	MEK1 →	+0.476	+2.321	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.109	-1.658	.023	.021	3	2
UCEC	PCNA →	+0.261	+2.321	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.201	-3.999	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

14-3-3_beta by RTN4 expression — COAD

Explore this box plot interactively →