RTN4

Across TCGA cell cohorts, RTN4 mutation is significantly associated with the RNA expression of many other genes, with 244 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RTN4-associated genes across cancer lineages are OR2D3, CCDC134, and CYP2U1. Each is linked with RTN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN4-to-partner and partner-to-RTN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2D3 grouped by RTN4-low versus RTN4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN4→partner) and Y-score (partner→RTN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	OR2D3 →	+0.028	+3.990	<.001	.003	3	2
BLOOD_Leukemia	CCDC134 →	+0.508	+3.351	.005	.003	3	2
BLOOD_Leukemia	CYP2U1 →	+1.194	+3.351	<.001	.003	3	2
BLOOD_Leukemia	COX11 →	+0.681	+3.120	.004	.009	3	2
BLOOD_Leukemia	SFT2D3 →	+0.448	+3.258	<.001	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	C16orf92 →	+0.037	+4.357	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 244 associations by consensus.

OR2D3 by RTN4 expression — OVARY

Explore this box plot interactively →