RTN3

Across TCGA pan-cancer cohorts, RTN3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RTN3 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RTN3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated RTN3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

KIRC, UCEC, and STAD are the cancer types where RTN3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.154	0.631	<.001	42	view →
UCEC	DFS	Median	II,III,IV	0.937	0.431	.009	24	view →
STAD	OS	Median	IV	0.805	0.283	.031	7	view →
LUAD	OS	Median	All	0.323	0.834	.003	6	view →
COAD	DFS	Median	All	0.527	0.785	.005	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RTN3–KIRC (OS)

Open the KIRC breakdown →