RTN3

Across TCGA pan-cancer cohorts, RTN3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated RTN3 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RTN3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RTN3 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where RTN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.202	0.985	.007	36	view →
PDAC	DFS	Quartile	All	0.601	0.815	.022	6	view →
HNSC	OS	Median	All	0.449	1.000	.023	6	view →
UCEC	DFS	Tertile	All	0.931	1.000	.042	2	view →
GBM	DFS	Quartile	All	0.856	0.632	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

RTN3–CCRCC (OS)

Open the CCRCC breakdown →