RTN3

Across TCGA patient cohorts, RTN3 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN3-associated genes across cancer lineages are Caspase-7-cleavedD198, Chk2_pT68, and FoxM1. Each is linked with RTN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both RTN3-to-partner and partner-to-RTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RTN3-low versus RTN3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN3→partner) and Y-score (partner→RTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.714	+2.434	<.001	.001	3	4
BLCA	Chk2_pT68 →	+0.160	+2.820	.045	.035	3	2
UCEC	FoxM1 →	+0.234	+1.807	.008	.004	3	2
UCEC	IRS1 →	+0.142	+1.247	.045	.045	3	2
UCEC	PCNA →	+0.279	+3.000	<.001	<.001	3	2
UCEC	ASNS →	+0.375	+1.700	.002	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by RTN3 expression — UCEC

Explore this box plot interactively →