RTN3

Across TCGA cell cohorts, RTN3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible RTN3-associated genes across cancer lineages are KRTAP6-3, GUCA2B, and SLC38A8. Each is linked with RTN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN3-to-partner and partner-to-RTN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-3 grouped by RTN3-low versus RTN3-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN3→partner) and Y-score (partner→RTN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP6-3 →	+0.174	+5.029	<.001	.006	3	2
CNS	GUCA2B →	+0.050	+4.981	<.001	.008	3	2
LARGE_INTESTINE	SLC38A8 →	+0.427	+3.404	.005	.006	3	1
LARGE_INTESTINE	GUCA1A →	+0.044	+2.841	<.001	.009	3	1
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	BTBD16 →	+0.071	+3.959	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

KRTAP6-3 by RTN3 expression — LUNG_SCLC

Explore this box plot interactively →