RTN2

Across TCGA patient cohorts, RTN2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTN2-associated genes across cancer lineages are c-Met_pY1235, TFRC, and 14-3-3_beta. Each is linked with RTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN2-to-partner and partner-to-RTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by RTN2-low versus RTN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN2→partner) and Y-score (partner→RTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.064	+3.331	.041	.005	3	2
SKCM	TFRC →	+0.675	+3.000	.019	.035	3	1
UCEC	14-3-3_beta →	-0.109	-2.301	.010	.034	3	1
UCEC	INPP4B →	-0.315	-3.169	.021	.018	3	1
UCEC	MEK1 →	+0.394	+2.584	.011	.010	3	1
UCEC	PKC-a →	+0.362	+3.183	.035	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

c-Met_pY1235 by RTN2 expression — UCEC

Explore this box plot interactively →