RTN2

Across TCGA cell cohorts, RTN2 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RTN2-associated genes across cancer lineages are CENPVL1, OR4X2, and HCRTR1. Each is linked with RTN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RTN2-to-partner and partner-to-RTN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by RTN2-low versus RTN2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTN2→partner) and Y-score (partner→RTN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CENPVL1 →	+0.055	+3.040	<.001	.002	3	2
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SKIN	HCRTR1 →	+0.030	+2.839	.009	.004	3	1
SKIN	RFPL3 →	+0.053	+3.584	<.001	<.001	3	1
SKIN	DRD1 →	+0.118	+2.672	.002	.004	3	1
SKIN	GLRA4 →	+0.022	+2.560	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

CENPVL1 by RTN2 expression — SKIN

Explore this box plot interactively →