Across TCGA pan-cancer cohorts, RTL8B Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated RTL8B data layer compared with 30 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RTL8B Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated RTL8B expression acts as an unfavorable survival marker.

HNSC, LGG, and LIHC are the cancer types where RTL8B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.122	0.685	.001	33	view →
LGG	OS	Median	All	0.498	0.897	<.001	14	view →
LIHC	OS	Median	All	0.226	0.773	.008	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: RTL8B tumor-vs-normal RNA expression · all RTL8B data types