Across TCGA patient cohorts, RTL8B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RTL8B-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Fibronectin. Each is linked with RTL8B in more than 1 cancer types. Because this analysis shows association rather than direction, both RTL8B-to-partner and partner-to-RTL8B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RTL8B→partner) and Y-score (partner→RTL8B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.110	-3.558	.003	.002	3	1
UCEC	ERK2 →	+0.170	+3.700	.018	.001	3	1
UCEC	Fibronectin →	-0.261	-3.160	.035	.019	3	1
UCEC	GATA6 →	-0.227	-2.985	<.001	.034	3	1
UCEC	HER2 →	+0.349	+1.765	.040	.014	3	1
UCEC	HSP70 →	-0.308	-1.990	.041	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

RTL8B survival (RNA) · tumor vs normal (RNA) · all RTL8B data types